|
KMID : 0364320180430010019
|
|
Journal of East-West Medicine
2018 Volume.43 No. 1 p.19 ~ p.47
|
|
|
The Effects of Soeumin-sohabheangwon(SHHW) extract on inhibition of impairment of learning and memory, and acetylcholinesterase in the Alzheimer's Disease Model
|
|
Kim Bo-Young
|
|
|
Abstract
|
|
|
|
This experiment was designed to investigate the effect of Soeumin- ohabheangwon (SHHW) on the Alzheimer's disease. The effects of SHHW extract(100, 10, 1 ㎍/㎖) on APP, AChE, GFAP mRNA of PC-12 cell treated by Aβ and AChE activity of PC-12 cell lysate treated by Aβ and IL-1β, IL-6, TNF-α mRNA of THP-1 cell treatment with LPS and behavior of memory deficit rats induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. The results were summarized as follows ; 1. SHHW extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by Aβ. APP, AChE mRNA were suppressed dose-dependently. 2. SHHW extract suppressed AChE activity in cell lysate of PC-12 cell treated by Aβ. 3. SHHW extract suppressed IL-1β, IL-6, TNF-α mRNA in TNF-1 cell treated with LPS. IL-6, TNF-α mRNA were suppressed dose-dependently. 4. SHHW extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. 5. SHHW extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. According to the above results, it is suggested that SHHW extract might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|